Prodiamine Review – (2020 Edition) – Is It Effective?

Looking for an in-depth review of prodiamine?

Perfect! In this Pest Strategies guide you’ll learn:

  • What Prodiamine is and why you might use it
  • How it works to help your lawn
  • How to use it and get amazing results
  • Our review of this product

And much more!

prodiamine review

Looking For A Trusted Exterminator?

Below are our top ranked exterminators we’ve reviewed for each type of pest. We’ve arranged it so you can get free quotes in just a couple minutes. 

Rating: 97.50

Our #1 Ranked For: Ants, Roaches, Spiders, and Rodents Issues

Rating: 97.00

Our #1 Ranked For: Termites, Bed Bugs, and Larger Infestations

Rating: 95.70

Our #1 Ranked For: Mosquito Removal, Fleas, Ticks, Wasps, And Other Stinging Insects

Our Review of Prodiamine

Overall Rating (5 Stars)

On a scale of one to five, with five being best, we give Prodiamine five stars.


  • A selective, pre-emergent herbicide
  • Impressive list of weeds controlled by it
  • One jug covers 7,000 to 10,000 square feet
  • It can be used in both the spring and the fall
  • It is cheaper than older brand name products
  • Use in nurseries, landscape, turf, Christmas tree farms, and golf courses


  • Won’t control established weeds or perennial grasses

Want To Solve Your Pest Problem Now?

We’ve partnered with Terminix to bring you exclusive discounts and priority service for your pest control needs. Click to get your free instant price quote.

Limited Time: Save $50 off your pest control service.

What Is Prodiamine?

It is a pre-emergent herbicide for killing weeds before they sprout and grow through the surface of the soil. The EPA has approved it for use on golf courses, on established turf grasses, lawns, and sod nurseries.

It has also been approved for use in conifer and hardwood seedling nurseries, managed rights-of-way for transportation systems and utilities (including electrical transmission lines and gas lines), roadsides, railways, tank farms, pumping stations, and more.

It is manufactured in Raleigh, North Carolina, and can be somewhat harmful if the dust is inhaled. It should not be used on land that will be grazed or used by livestock, nor should it be sprayed on plants that are intended for human consumption.

The chemical name is 2,4-dinitro-3-N,3-N-dipropyl-6-(trifluoromethyl)benzene-1,3-diamine and takes the form of small gold, yellowish granules that dissolve in water before being sprayed.

What’s The Active Ingredient In Prodiamine?

Prodiamine is the active ingredient. In this case, the product name, Prodiamine 65 WDG, was taken from the common name for the herbicide. It’s a professional herbicide so there aren’t a lot of fancy trade names for it.

Does Prodiamine Work?

Prodiamine works beautifully, if and only if, you use it correctly. If you use it incorrectly, you’ll get partial results at best, no results at worst. We’ll discuss how to use it then give you some reasons why it might not work.

How To Use A Herbicide

  1. The amount of water you use when spraying Prodiamine is incidental since it only acts as a carrying agent. When using granular herbicides, you need to follow a couple of simple, but inflexible rules. The amount of water is the first one.

Fill your handheld sprayer or backpack sprayer with water only. Mark off 1000 square feet or one acre and begin spraying the water at your normal walking speed, covering every inch of the ground in the area. This is your test run.

Read Also: Top 5 Best Pump Sprayers (2020 Review)

When you’re finished with the test run, measure how much water you used and write it down. You’ll need it later.

When you’re ready to spray the herbicide, put in the amount of water you used during your test run, add the correct amount of herbicide for the size of the area you’re treating, and mix it vigorously.

When you begin spraying, make sure you do it at the same speed as during your test run. If you spray too much or too little any in one spot, you’ll create problems for yourself later on.

  1. The second rule concerns the timing of your spraying efforts. Prodiamine is a pre-emergent herbicide. This means it only works on plants (weeds) that haven’t emerged from the soil yet.

If the weeds have already germinated and poked their way through the soil, it’s too late to kill them, even if they’re listed on the label as ones that Prodiamine will kill.

You need to familiarize yourself with the weeds in your area and find out as much about them as you can. You need to know when they germinate because this will tell you when to spray the herbicide to kill them.

For example, to kill crabgrass in the southern parts of Texas, the Deep South, Florida, Southern California, and parts of Arizona, between January and March is when it germinates in that part of the country, so you need to spray early.

Across the northern part of the United States bordering Canada, crabgrass doesn’t germinate until after May 30.

Other areas of the country fall somewhere between those two extremes. 

Reasons A Herbicide Might Not Work

  • The most common reason for herbicide failure is one we’ve already touched on, spraying after the weeds have already emerged. We have to repeat; a pre-emergent herbicide will not kill existing weeds.
  • Failing to calibrate your equipment to determine how much water is required for the area you’re treating will lead to uneven amounts of herbicide being deposited.
  • Topdressing with fertilizer on the treated areas prevents herbicides from working. As of this writing, researchers are still struggling to understand the mechanism involved.
  • Trying to save money by using a lower herbicide rate results in a weakened herbicide barrier that will degrade more quickly than one at full strength. Herbicides can be expensive, but one that doesn’t work because it’s diluted is even worse.
  • Over-watering your plants can cause the herbicide to be leached away. Herbicides sink into the soil after being sprayed but they don’t attach to it. Consequently, they can be washed away by too much water.
did you know prodiamine review fact

  • Not enough water is the opposite problem. Most herbicides, including Prodiamine, require 0.5 inches of water within 14 days of application. You should get that half-inch of water on there on the first day or two. Waiting will degrade the herbicide – badly.
  • The weed you’re treating for isn’t on the label. We’ve seen this one far too often. Make sure the herbicide you get lists your weeds on the label. If it doesn’t, you’re not going to get any results.
  • Pre-emergent herbicides sink into the ground and form a chemical barrier in the soil, from half-an-inch to an inch thick. Disrupting that barrier – poking the ground, dragging things across it, raking, etc. – will allow weeds to grow without contacting the herbicide.

Read Also: What are the top weed killers for your grass?

Want To Solve Your Pest Problem Now?

We’ve partnered with Terminix to bring you exclusive discounts and priority service for your pest control needs. Click to get your free instant price quote.

Limited Time: Save $50 off your pest control service.

Is Prodiamine Harmful To Humans or Children?

The toxicity rating for Prodiamine is Not Acutely Toxic to people and other mammals. There is no long-term toxicity rating for people or animals, nor is there any information regarding its impact on honeybees. It does have a high runoff risk in the event of rain.

The REI (Restricted Interval Entry) for Prodiamine is 12 hours. That means you need to wait 12 hours after spraying to enter the treated area. This gives it time to leach into the ground and fully dry.

The label recommends PPE (Personal Protective Equipment) during spraying of coveralls, chemical resistant gloves, boots, and socks. As long as you follow these simple rules, it will be safe for you and your children.

Is Prodiamine Safe For Cats & Dogs?

The precautions and warnings applicable to people also apply to cats and dogs. However, cats and dogs tend to be more sensitive to chemicals than people, especially the smaller ones. There’s no direct evidence it’s harmful but better safe than sorry.

Keep all your pets and livestock away from the area while you’re spraying and for the full 12 hours afterward too. Once it’s completely dry, you can allow them to enter the area.

Prodiamine Vs Other Products?

If you’re curious how Prodiamine stacks up against other herbicides, it does quite well. We’ll briefly compare it to three other herbicides and let you decide.

Prodiamine vs Pendulum 2G

The active ingredient in Pendulum is pendimethalin. It is labeled for use as a pre-emergent against most annual grasses and broadleaf weeds. It can be used around field crops such as corn, cotton, peanuts, potatoes, rice, tobacco, and sunflowers.

It is primarily a pre-emergent herbicide but with some use as an early post-emergent one as well. It has a wider use than Prodiamine but also a somewhat higher level of toxicity, so there is a trade-off.

Prodiamine vs Dacthal 75WP

The active ingredient in Dacthal 75WP is DCPA aka chlorthal dimethyl. This one is so safe that the LD50 (lethal dose to 50% of test animals) values are difficult to obtain. It takes over 10,000 milligrams per kilogram of a dog’s weight to cause measurable harm.

Like Prodiamine, it is a pre-emergent that kills a wide range of annual grasses but Prodiamine kills more broadleaf weeds.

Prodiamine vs Preen

The active ingredient in Preen is trifluralin. In 1979, the EPA brought trifluralin under special review because of N-nitrosamine contaminants that were known to cause tumors.

The manufacturer has resolved the problem since then, but the EPA has imposed a requirement that N-nitrosamine contaminant levels have to remain below 0.5 ppm, so you might see that on the label.

It’s Not Acutely Toxic to people and other mammals and kills much the same weeds as Prodiamine. Depending on where you purchase it, it might be a bit more expensive though.

Other Chemical Product Reviews

Curious about other pest control products? Check out our other detailed guides to help you deal with your pest problems.

Looking for an expert review of permethrin SFR?Perfect, you're in the right place! In this guide you’ll learn:In this guide[...]
In this guide you’ll learn the following: What Talstar is How Talstar can be used The safety record of Talstar[...]
Looking for an in-depth review of Taurus SC?Perfect! In this Pest Strategies guide you’ll learn:What Taurus SC is and isn’tHow[...]
Looking for an in-depth review of prodiamine?Perfect! In this Pest Strategies guide you’ll learn:What Prodiamine is and why you might[...]
Looking for the top bug sprays that are pet friendly?Perfect! In this Pest Strategies guide you’ll learn:What a pet safe[...]
Looking for an in-depth review of bifen IT?Perfect. you're in the right place! In this Pest Strategies guide you’ll learn:What[...]

Get Your Free Quote In Seconds

Because pest control products can be dangerous to your family if mishandled, we always recommend consulting with an exterminator even if just to ask for advice on how to apply pest control products yourself.

Our pest experts review each company for quality, cost, customer service, safety, and 100’s of other important factors and assess a rating out of 100. Below are our top 3 picks based on that review for pest removal. We’ve set up a direct line with each company so you can get fast free quotes right now.

Rating: 97.50

Our #1 Ranked For: Ants, Roaches, Spiders, and Rodents Issues

Rating: 97.00

Our #1 Ranked For: Termites, Bed Bugs, and Larger Infestations

Rating: 95.70

Our #1 Ranked For: Mosquito Removal, Fleas, Ticks, Wasps, And Other Stinging Insects

Leave a Comment